New applications for Covalent Ligand Directed Release chemistry

Speaker: Prof. Nir London, Weizmann Organiser: C. Heinis <p>Covalent Ligand Directed Release (CoLDR) chemistry has emerged as a versatile strategy for targeted covalent modulation of protein function. In this talk, I will present several new (unpublished) applications of CoLDR chemistry spanning molecular optimization, targeted protein degradation, and protein activation. I will describe the development of high-throughput synthetic approaches for rapid generation and optimization of CoLDR inhibitor libraries. I will then present a high-throughput screening platform for the discovery of novel CoLDR-based PROTACs and will discuss the design and evalua