Understanding and Predicting the Membrane Permeability of Macrocyclic Peptides Based on Large-Scale Data

Speaker: Prof. Shinsuke Sando, University of Tokyo Organiser: C. Heinis <p>Macrocyclic peptides are promising molecules for targeting intracellular protein–protein interactions and other challenging biological targets. However, their poor membrane permeability often limits their biological and therapeutic applications. Understanding the structural factors that govern passive membrane permeation is therefore essential for the rational design of cell-permeable macrocyclic peptides.<br> <br> In this seminar, I will present our recent efforts to understand and predict the membrane permeability of macrocyclic peptides using large-scale experimental data, conformation